美国凯斯西储大学2020年博士后招聘(生物医学,分子和细胞生物学)
Dr. Wenquan Zou, in the Departments of Pathology and Neurology at the Case Western Reserve University School of Medicine, Cleveland, Ohio, is seeking outstanding candidates for two postdoctoral fellow positions. Successful candidates must hold a PhD or an equivalent degree in biomedicine or related studies with background in molecular and cellular biology. A successful candidate must have hands-on experience in E. coli recombinant protein production. Applicants with skills of real-time quaking induced conversion (RT-QuIC) and/or serial protein misfolding cyclic amplification (sPMCA) will be a plus. Other research experience in mouse models, primary cell cultures, protein folding, biochemistry, molecular and cellular biology, imaging and other related fields will also be helpful.
The Zou laboratory aims to elucidate the pathogenesis and early diagnosis of neurodegenerative diseases that are all associated with abnormally misfolded proteins. These diseases include, but not limited to, prion diseases, Parkinson’s disease and Alzheimer’s disease. Currently, the lab is studying prion disease, Parkinson’s disease, and Alzheimer’s disease, with a wide range of approaches, from in vitro biochemical studies with human tissues, cultured cells, and recombinant proteins to in vivo transmission study with animal models, especially RT-QuIC and sPMCA assays.
The interested candidates can check their recent publications in this area in order to have a better understanding of their research work:
Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ. Early preclinical detection of prions in the skin of prion-infected animals. Nat Commun. 2019 Jan 16;10(1):247. doi: 10.1038/s41467-018-08130-9.
Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ. Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease. Sci Transl Med. 2017 Nov 22;9(417). pii: eaam7785. doi: 10.1126/scitranslmed.aam7785.
Abskharon R, Dang J, Elfarash A, Wang Z, Shen P, Zou LS, Hassan S, Wang F, Fujioka H, Steyaert J, Mulaj M, Surewicz WK, Castilla J, Wohlkonig A, Zou WQ. Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors. Microb Cell Fact. 2017 Oct 4;16(1):170. doi: 10.1186/s12934-017-0782-x.
声明:凡本网注明"来源:XXX"的文/图等稿件,本网转载出于传递更多信息及方便产业探讨之目的,并不意味着本站赞同其观点或证实其内容的真实性,文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用,须保留本网站注明的“来源”,并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜,请与我们联系。
微信公众号
高校博士后招聘
+more科研机构博士后招聘
+more-
中国科学院烟台海岸带生物学与生物资源利用重点实验室2024年招聘
-
北京航天试验技术研究所博士后科研工作站2024年招收简章
-
中国科学院天津工业生物技术研究所系统与合成生物技术研究组20
-
中国科学院科技战略咨询研究院创新发展政策研究所2024年特别研究
-
中国科学院科技战略咨询研究院系统分析与管理研究所2024年招聘特
-
中国科学院科技战略咨询研究院学部科学规范与伦理研究支撑中心
-
中国农业科学院茶叶研究所2024年度招收博士后研究人员公告
-
国家文物局考古研究中心2024年公开招聘出站博士后公告
-
中国科学院苏州纳米技术与纳米仿生研究所纳米加工平台2024年招聘
-
国家纳米科学中心曹宇虹课题组2024年招聘副研究员、特别研究助理