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Job Description
The Division of Surgical Oncology (Department of Surgery) at the University of Illinois at Chicago is seeking to fill a Postdoctoral Research Associate position for a funded project in the area of Molecular Oncology. The main focus of research will be to elucidate in-depth the mechanism of cancer cell resistance to apoptosis, identify potential targets and design strategies to ameliorate resistance. The laboratory is equipped with state-of-the art equipments and employs the latest molecular, biochemical and cell biological approaches in cell culture and animal models of cancer.
Doctorate degree earned within the last 5 years, with relevant publications and with a strong research background in cell biology, molecular biology, and cloning is required. Candidates with 3-4 years of postdoctoral experience is preferred. Candidates should have demonstrated skills in western blotting, co-immunoprecipitation, PCR, qPCR, gene arrays, kinase assays, cell culture, transfection, gene cloning and in various in vivo xenograft and metastasis cancer models. Ability to work in a competitive environment, strong communication skills in English, demonstrated creativity and independence, and high motivation are strongly desirable.
Selected References:
1. Senthivinayagam S, Mishra P, Paramasivam SK, Yallapragada S, Chatterjee M, Wong L, Rana A, and Rana B. Caspase mediated cleavage of -catenin precedes drug induced apoptosis in resistant cancer cells. J. Biol. Chem. 2009; 284, 13577-88.
2. Mishra P, Senthivinayagam S, Rangasamy V, Sondarva G and Rana B. Mixed lineage Kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation. Mol. Endocrinol. 2010; 24, 598-607.
3. Thylur RP, Senthivinayagam S, Campbell EM, Rangasamy V, Thorenoor N, Sondarva G, Mehrotra S, Mishra P, Zook E, Le PT, Rana A and Rana B. Mixed Lineage Kinase 3 modulates -catenin signaling in cancer cells. J. Biol. Chem. 2011; 286, 37470-82.
4. Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A. Mixed-Lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc. Natl. Acad. Sci. USA. 2012 May 7 [Epub ahead of print].
5. Das S, Sondarva G, Viswakarma N, Nair RS, Osipo C, Tzivion G, Rana B and Rana A. Her2 impedes MLK3 kinase activity to support breast cancer cell survival. J. Biol. Chem. 2015; 290, 21705-12.
6. Santha S, Viswakarma N, Das S, Rana A and Rana B. TRAIL-Troglitazone-induced apoptosis in prostate Cancer Cells involve AMP-activated protein kinase. J. Biol. Chem. 2015; 290, 21865-75. |
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