美国密西根安娜堡大学化学院招聘两名酶/蛋白设计研究博士后
Postdoctoral Research Positions - Enzymology / Protein Design
Employer: University of Michigan, Department of Chemistry
Location: University of Michigan, Ann Arbor, Michigan
Salary: Commensurate with experience
Position Type: Full Time
Job Type: Postdoc
Two post-doctoral positions are available immediately to work on projects funded by the National Institutes of Health (NIH) and the Defense Threat Reduction Agency (DTRA).
Cellular targets and mechanism of action of viperin (NIH)
Eukaryotic cells have developed sophisticated defenses aimed at limiting viral replication and thereby preventing infection from escalating to other cells. A key enzyme in the antiviral response is viperin, which has been shown to restrict the infectivity of a number of important human viruses including influenza A, HIV and hepatitis C. However, the biochemical basis of viperin’s antiviral activity remains unknown. This project will employ proteomics methods to identify the protein targets of viperin in human cell cultures. The interactions of the target proteins with viperin will then be studied in more detail in vitro using a variety of biochemical techniques.
Enzyme-based sensors for heavy metal ions (DTRA)
Contamination by heavy metals poses an important environmental health problem in many contexts. The use of switchable enzymes to detect metal ions has the potential to produce extremely sensitive and specific real-time sensors for heavy metal contamination. This collaborative project will combine aspects of protein design and enzymology to engineer enzymes that are activated to catalyze the hydrolysis of fluorogenic substrates by the binding of specific heavy metal ions; thereby achieving amplification of the signal. The engineered enzymes will be characterized using a variety of spectroscopic and kinetic techniques with the eventual goal of integrating them into functional sensors.
Qualifications
Applicants should have recently obtained or be about to obtain a Ph.D. in a relevant area of research such as enzymology, protein design, proteomics, or bioinorganic chemistry and will have a demonstrated record of productivity.
Applicants should be highly motivated and able to work independently. They should be prepared to assume leadership of their projects and mentor graduates students and undergraduates working along side them.
Applicants should e-mail their curriculum vitae and names of three references to:
Prof. Neil Marsh, e-mailnmarsh@umich.edu
Informal inquiries regarding these positions are welcome
声明:凡本网注明"来源:XXX"的文/图等稿件,本网转载出于传递更多信息及方便产业探讨之目的,并不意味着本站赞同其观点或证实其内容的真实性,文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用,须保留本网站注明的“来源”,并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜,请与我们联系。
微信公众号
高校博士后招聘
+more科研机构博士后招聘
+more-
中国科学院烟台海岸带生物学与生物资源利用重点实验室2024年招聘
-
北京航天试验技术研究所博士后科研工作站2024年招收简章
-
中国科学院天津工业生物技术研究所系统与合成生物技术研究组20
-
中国科学院科技战略咨询研究院创新发展政策研究所2024年特别研究
-
中国科学院科技战略咨询研究院系统分析与管理研究所2024年招聘特
-
中国科学院科技战略咨询研究院学部科学规范与伦理研究支撑中心
-
中国农业科学院茶叶研究所2024年度招收博士后研究人员公告
-
国家文物局考古研究中心2024年公开招聘出站博士后公告
-
中国科学院苏州纳米技术与纳米仿生研究所纳米加工平台2024年招聘
-
国家纳米科学中心曹宇虹课题组2024年招聘副研究员、特别研究助理