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Job Description
Seeking Ph.D. graduates for Post-Doctoral Scholar positions in the Mulder Lab, Dept. of Biochemistry & Molecular Biology, Penn State Hershey College of Medicine, Hershey, PA.
Research is focused on tumor cell signaling, trafficking, and cell movement/migration, with a particular emphasis on colon and pancreatic cancer, as well as epithelial cells. Research also pertains to TGFß, anti-cancer therapeutics, cancer invasion, km23, small GTPases, motility-associated protrusive structures, motor proteins, dynein, actin cytoskeleton.
Requirements include a Ph.D. in a relevant field, as well as relevant peer-reviewed molecular/cell biology publications. Must have demonstrated hands on experience with mammalian cell culture and basic molecular/cellular techniques (ie, WB, IP/blot, PCR, construct preparation, shRNA, IF, live imaging). Priority given to US citizens, permanent residents, and applicants with relevant expertise in published work.
Please send CV and contact information for 3 referees to Dr. Kathleen M. Mulder at kmm15@psu.edu. In your application, please indicate which of your publications demonstrate your hands on experience in the relevant molecular/cell techniques.
Penn State Hershey College of Medicine is located in a scenic countryside setting, with affordable living minutes from work, and moderate climate conditions. Located near the state capitol, Harrisburg, in south central PA, it is approximately 1.5 hours from Philadelphia, PA, or Baltimore, MD, and about 3 hours from New York City. Modern laboratory space is abundant and research instrumentation, technologies, and core facilities are state-of-the-art.
Mulder Lab Research Interests
We have identified the TGFβ receptor-interacting protein km23-1/dynlrb1, which plays an important role in TGFβ signal transduction, as well as in dynein-mediated intracellular transport of signaling cargoes to specialized locales. km23-1 also functions as a critical platform for the assembly of small GTPases, underlying its critical roles in cell signaling, motility, polarity, and in coupling TGFß receptor activation to activation of Ras effector pathways downstream. We are also investigating mechanisms of TGF-beta signaling in cancer and non-cancer cells, involving cell signaling, cell migration/invasion, actin cytoskeleton, motor proteins, intracellular trafficking, Ras, MAPKs, Smads, and dynein. Additional studies address how these events are altered in human cancers, as well as how km23-1 can be targeted therapeutically. The overall focus of the Mulder Lab is the identification of novel signal transduction-based therapeutics for human colon and pancreatic cancer.
http://www.futurity.org/health-medicine/protein-helps-colon-cancer-move-and-invade/
http://www.eurekalert.org/pub_releases/2013-06/ps-pii062713.php
http://news.psu.edu/story/280300/2013/06/27/research/protein-involved-colon-cancer-cells-ability-invade-other-cells |
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